Study: Influence of Genetics on Mental Health Depends on Environment

The same genes can make people more sensitive to their experiences, “for better of for worse,” psychologists argue.

By Tanya Lewis | July 20, 2016

Original Article Published on

The same genes could make a person feel happy or depressed, depending on their environment. Combining research on genetics and cognitive biases—our mental “filters” for interpreting the world—will contribute to a greater understanding of mental disorders and could lead to improved therapies, Elaine Fox of University of Oxford and Chris Beevers of the University of Texas at Austin suggest in a perspective published yesterday (July 19) inMolecular Psychiatry.

“We suggest that while no gene ‘causes’ mental ill health, some genes can make people more sensitive to the effects of their environment—for better and for worse,” Fox said in a statement.

Fox and Beevers reviewed studies on both mental health genetics and cognitive biases, attempting to explain how the two work in concert to influence mental health.

Studies show that cognitive bias can greatly influence sensitivity to one’s environment, Fox and Beevers reported in their perspective. For example, inducing a negative attentional bias can increase a person’s response to a stressful situation, whereas reducing the negative bias can decrease that person’s stress response. However, the small size and assumptions of these studies has limited their importance, according to Fox and Beevers.

Likewise, genetics studies have identified variants, such as the serotonin transporter-linked polymorphic region (5-HTTLPR) short (S) allele, which make people more sensitive to their environments. People with this S allele are more likely than people with the long (L) variant to develop psychiatric disorders after experiencing adversity in childhood, studies have shown.

“There is a lot of research about these biases, and a lot of research about genes that may make people susceptible to mental ill health,” Beevers said in the statement. “However, we suggest that it could make more sense to bring together these two areas of research.”



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